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The safety profile of retatrutide is similar to other incretin-based therapies, with the most commonly reported adverse events being transient and mostly mild to moderate gastrointestinal symptoms, with the 4 mg starting dose group having a higher incidence than the 2 mg starting dose group

Exposure to substances that carry lead, such as some chocolates, canned foods, toothpastes, old paints, insecticides, ceramic and some pottery, and soldered pipes